Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (34): 6393-6396.doi: 10.3969/j.issn. 2095-4344.2012.34. 025

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Hemocompatibility of biomedical polymeric materials Design of anticoagulant materials○

Chen Bao-lin1, Wang Dong-an2, 3   

  1. 1Bureau of Scientific Research, Hulunbuir College, Hulunbuir 021008, Inner Mongolia Autonomous Region, China;
    2Institute of Polymer Sciences, Zhejiang University, Hangzhou 310027, Zhejiang Province, China;
    3Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, Tennessee, USA
  • Online:2012-08-19 Published:2012-08-19
  • About author:Chen Bao-lin, Professor, Bureau of Scientific Research, Hulunbuir College, Hulunbuir 021008, Inner Mongolia Autonomous Region, China baolinchenkyc@ sina.com

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Abstract:

BACKGROUND: Polymeric materials implanted into organism in vivo should have two basic performances: medical function and biocompatibility.
OBJECTIVE: To review design of anticoagulant materials and clotting mechanism of hemocompatible polymeric materials.
METHODS: A computer-based online search of PubMed database and Wanfang database was performed for articles published from 1953 to 2011 with English key words “biocompatibility, blood compatibility, bio-inert surface, bio-active surface” and Chinese key words “biocompatibility, anticoagulant materials, biomedical materials, medical polymeric materials”.
RESULTS AND CONCLUSION: the material surface is designed to improve surface hydrophilicity and hydrophobicity and to enhance hemocompatibility by reducing thrombosis through introduction of charged groups and bioactive substance. However, effects of surface modification to improve hemocompatibility are limited. Tissue engineering technique enables in situ culture of human endothelial cells on material surface to endothelialize the materials and improve hemocompatibility.

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